This is going to be very basic, because it is simple to tune for E85. I have HP Tuners so all I did was change my cylinder gain on the main fuel section from 1 to 1.3. it's not exact science, for example, 1.3 is what you want if you have actual 85% ethanol, but in the winter, the blend goes down to 70% so then you would enter 1.2. you can also use your maf sensor to see what to change the cylinder gain to, for example, if you are running 5% lean then you would richen it up by entering 1.22
here is a caveat, only mess with the cylinder gain if you are tuning for E85. if you need to adjust your maf sensor to dial in your car, that is different, and hopefully we can get a how-to going soon.
once you change your cylinder gain, it's usually a good idea to do a maf adjustment because it will probably be different.
There is also a way to make your car start easier with E85 because some people have cold start issues, but I don't remember how I did it.
I've also heard that you can install 42.5 lb injectors and run E85 without tuning because they are 30% bigger than stock.
here are a few things I've learned about E85 over the years: One, ethanol is oxygenated, so it has better duration than unleaded gasoline. Two, ethanol is cleaner than gasoline. Three, it takes about 30% more E85 so expect worse gas mileage. Four, E85 has a propensity to attract water, so if you are like me and store it in your garage, it is best to keep it sealed up in a metal container. Five, E85 has an octane rating of around 105, and it also works well as a chemical intercooler, so you can run a smaller pulley on the supercharger if you have access to a tuner, have bigger injectors and can get E85 somewhat easy. I drove 85 miles to get E85 and store it in a 55 gallon drum. I will buy like 35 gallons at a time and top off my drum. Lastly if you are converting to E85, don't be like me and cheap out on 42 lb injectors because if you are going to run E85, you will max them.
I am currently running a 3.0 pulley with an XP cam, mildly ported heads a gen 5, water/methanol injection and E85 with no kr, and 42 lb injectors that are at 90% duty cycle, so almost maxed out. with 60 lb injectors I would have a huge amount of headroom.